[1]石晓华,周彩荣,蒋登高,等.医药中间体2-对氯苄基吡啶的合成与分析[J].郑州大学学报(工学版),2001,22(04):96-98.[doi:10.3969/j.issn.1671-6833.2001.04.027]
　SHI Xiaohua,ZHOU Cairong,Jiang Denggao,et al.Synthesis and analysis of pharmaceutical intermediate 2-p-chlorobenzylpyridine[J].Journal of Zhengzhou University (Engineering Science),2001,22(04):96-98.[doi:10.3969/j.issn.1671-6833.2001.04.027]

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医药中间体2-对氯苄基吡啶的合成与分析()

分享到：

《郑州大学学报(工学版)》[ISSN:1671-6833/CN:41-1339/T]

卷:

22

期数:

2001年04期

页码:

96-98

栏目:

出版日期:

1900-01-01

文章信息/Info

Title:

Synthesis and analysis of pharmaceutical intermediate 2-p-chlorobenzylpyridine

作者:

石晓华; 周彩荣; 蒋登高; 等.

郑州大学化学工程学院,, 郑州大学化学工程学院,, 郑州大学化学工程学院,, 郑州大学化学工程学院,, 郑州大学化学工程学院,, 郑州大学化学工程学院,

Author(s):

SHI Xiaohua; ZHOU Cairong; Jiang Denggao; etc

关键词:

2-对氯苄基吡啶;  对氯氯苄;  盐酸吡啶;  合成

Keywords:

2-p-Chlorobenzylpyridine;  p-chlorobenzyl chloride;  Pyridine hydrochloride;  Synthesis

DOI:

10.3969/j.issn.1671-6833.2001.04.027

文献标志码:

A

摘要:

以对氯氯苄与盐酸吡啶缩合法制备2-对氯苄基吡啶.考察了用料配比、催化剂用量、反应时间、反应温度、保温时间等因素对产品收率的影响,确定了较佳工艺条件为:n(对氯氯苄)∶n(盐酸吡啶)=1.6∶1.0,m(氯化铜)∶m(盐酸吡啶)=15∶100,反应温度160～170 ℃,反应时间2 h,保温时间7 h,无水吡啶加入量10 ml.在较佳反应条件下,2-对氯苄基吡啶的收率可达58.4%,并用气相色谱法程序升温分析该反应体系,效果良好.

Abstract:

2-p-chlorobenzylpyridine was prepared by p-chlorobenzyl chloride and pyridine hydrochloride. The effects of material ratio, catalyst dosage, reaction time, reaction temperature, holding time and other factors on product yield were investigated, and the optimal process conditions were determined as follows: n(p-chlorobenzyl chloride)∶n(pyridine hydrochloride)=1.6∶1.0, m(copper chloride)∶m(pyridine hydrochloride)=15:100, reaction temperature 160~170 °C, reaction time 2 h, holding time 7 h, anhydrous pyridine addition amount of 10 ml. Under optimal reaction conditions, the yield of 2-p-chlorobenzylpyridine can reach 58.4%. The reaction system was analyzed by gas chromatography, and the effect was good.

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