[1]李雯,尤启冬..2-氨基-3-三氟甲基苯甲酸的合成[J].郑州大学学报(工学版),2004,25(03):29-32.[doi:10.3969/j.issn.1671-6833.2004.03.008]
LI Wen,You Qidong.Synthesis of 2-amino-3-(trifluoromethyl)benzoic acid[J].Journal of Zhengzhou University (Engineering Science),2004,25(03):29-32.[doi:10.3969/j.issn.1671-6833.2004.03.008]
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2-氨基-3-三氟甲基苯甲酸的合成(
)
《郑州大学学报(工学版)》[ISSN:1671-6833/CN:41-1339/T]
- 卷:
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25卷
- 期数:
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2004年03期
- 页码:
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29-32
- 栏目:
-
- 出版日期:
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1900-01-01
文章信息/Info
- Title:
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Synthesis of 2-amino-3-(trifluoromethyl)benzoic acid
- 作者:
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李雯; 尤启冬.
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郑州大学化工学院,河南,郑州,450002;中国药科大学药学院,江苏,南京,210009, 中国药科大学药学院,江苏,南京,210009
- Author(s):
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LI Wen; You Qidong
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-
- 关键词:
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2-氨基-3-三氟甲基苯甲酸; 水合氯醛; 合成
- Keywords:
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- DOI:
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10.3969/j.issn.1671-6833.2004.03.008
- 文献标志码:
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A
- 摘要:
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2-氨基-3-三氟甲基苯甲酸为一个重要的药物合成中间体,对其合成方法进行了研究.以2-三氟甲基苯胺、水合氯醛、盐酸羟胺为原料,合成2-氨基的衍生物,然后在浓硫酸中转化为邻位二羰基衍生物,最后在氢氧化钠水溶液中用双氧水氧化得到2-氨基-3-三氟甲基苯甲酸.以2-三氟甲基苯胺计,2-氨基-3-三氟甲基苯甲酸的总收率为53.6%.所得的产物结构经元素分析、红外光谱、核磁共振谱所证实.该合成方法操作简便,收率较高,该方法所有合成步骤均为水相反应,易于工业化.
- Abstract:
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2-Amino-3-(trifluoromethyl)benzoic acid is an important drug synthesis intermediate, and its synthesis method has been studied. 2-trifluoromethylaniline, chloral hydrate and hydroxylamine hydrochloride were used as raw materials to synthesize 2-amino derivatives, and then converted into o-dicarbonyl derivatives in concentrated sulfuric acid, and finally 2-amino-3-trifluoromethylbenzoic acid was obtained by oxidation with hydrogen peroxide in sodium hydroxide aqueous solution. The total yield of 2-amino-2-(trifluoromethyl)benzoic acid was 3.53% based on 6-(trifluoromethyl)aniline. The synthesis method is easy to operate and has high yield, and all the synthesis steps of the method are water-phase reaction, which is easy to industrialize.
更新日期/Last Update:
1900-01-01