The production of activated zinc oxide is usually prepared by the metathesis reaction of soluble zinc salt and soluble carbonate, and is prepared after processing. The method of producing activated zinc oxide with zinc roasted sand was introduced, and the technical conditions of the production process were studied, the process flow was based on zinc roasted sand as raw material, directly reacted with carbonized mother liquor after acid leaching and purification, and then decomposed into activated zinc oxide after sedimentation, its quality met the GB 3185-87 first-class standard, the main content was ≥ 99.7%, the specific surface area was ≥ 71 m2/g, and the specific surface was proportional to the activity and the crystallinity. The process has a wide range of raw materials, strong adaptability, high waste liquid recovery rate, no pollution, low production cost, high quality, strong activity, and strong market competitiveness.