[1]王珂,张宏波,安博,等.磁流体的非均匀分布对磁感应热疗温度场的影响[J].郑州大学学报(工学版),2021,42(04):40-46.[doi:10.13705/j.issn.1671-6833.2021.04.005]
　Wang Ke,Zhang Hongbo,Anbo,et al.Analysis of the Influence of the Non-uniform Distribution of Magnetic Field and Magnetic Fluid on the Temperature Field in Magnetic Induction Hyperthermia[J].Journal of Zhengzhou University (Engineering Science),2021,42(04):40-46.[doi:10.13705/j.issn.1671-6833.2021.04.005]

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磁流体的非均匀分布对磁感应热疗温度场的影响()

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《郑州大学学报(工学版)》[ISSN:1671-6833/CN:41-1339/T]

卷:

42

期数:

2021年04期

页码:

40-46

栏目:

出版日期:

2021-07-30

文章信息/Info

Title:

Analysis of the Influence of the Non-uniform Distribution of Magnetic Field and Magnetic Fluid on the Temperature Field in Magnetic Induction Hyperthermia

作者:

王珂; 张宏波; 安博; 张璐; 王永庆

郑州大学力学与安全工程学院;郑州大学河南省过程与传热重点实验室;郑州大学机械与动力工程学院;

Author(s):

Wang Ke; Zhang Hongbo; Anbo; Zhang Lu; Wang Yongqing;

School of Mechanics and Safety Engineering of Zhengzhou University; Key Laboratory of the Process and heat transfer of Zhengzhou University Henan Province; School of Mechanical and Power Engineering, Zhengzhou University;

关键词:

磁流体; 热疗; 温度场; 磁场

Keywords:

magnetic fluid; hyperthermia; temperature field; magnetic field

DOI:

10.13705/j.issn.1671-6833.2021.04.005

文献标志码:

A

摘要:

通过研究温度场分布的均匀性来改善磁感应热疗的治疗效果，探究磁场和磁流体非均匀分布对温度场的影响，建立了涉及磁场、产热模型及生物传热的模型。采用有限元方法进行数值求解，对产热模型进行优化，考虑磁场非均匀分布和磁流体注射后浓度分布的差异，从而获得准确的生物组织温度分布特征。结果表明：温差随着生物组织中心与磁场中心偏移距离的增大而增大，偏移10mm时会造成1℃的温度差异；非等剂量多点注射使温度场分布更加均匀，可有效避免组织内温度过高；注射体积不变，5点注射与7点注射相比，治疗温度42℃以上体积分数明显较小。

Abstract:

Since the uniformity of the temperature field distribution determines the therapeutic effect of magnetic fluid hyperthermia,the distribution characteristics of the temperature field are closely related to the magnetic field distribution and the magnetic fluid distribution.In this article,the non-uniform distribution of the magnetic field produced by the actual Helmholtz coil was considered,and the influence of the non-uniform distribution of the magnetic fluid on the temperature field were further explored based on the multi-point injection strategy,and a theoretical basis for the clinical application of magnetic fluid hyperthermia was provided.This paper took the temperature field distribution in biological tissues during magnetic fluid hyperthermia as the research object,and aimed to maximize the volume fraction in tumor tissues up to 42～46 ℃ to explore the influence of different center-border injection ratios on the temperature field,thereby increasing the uniformity of the temperature field distribution.The biological tissue was simplified into a concentric sphere model,and a physical model combining the magnetic field,the heat generation power of the magnetic fluid and the biological heat transfer was established,and the finite element method was used to numerically solve the model.In order to consider the actual situation of magnetic fluid hyperthermia,the physical model analyzed the difference in the distribution of blood perfusion rate and the concentration of magnetic fluid after the temperature of the biological tissue changes.The results indicated that with the increasing of the offset distance between the center of the biological tissue and magnetic field,the temperature difference increased;when the offset was 10 mm,it would cause a temperature difference of 1 ℃;therefore,when there was a big difference between the center of the biological tissue and the center of the magnetic field,the actual magnetic field distribution should be considered;non-equal dose multi-point injection could make more tumor tissues be in a reasonable treatment temperature range.When the injection ratio k was 1～2,the volume fraction would be more affected;reduced the maximum temperature in the tissue,so that more tumor tissues were in a reasonable treatment temperature range;when the injection volume remained the same,compared with the 5-point injection,the 7-point injection had a larger volume fraction at a reasonable temperature,and its temperature spatial distribution was more uniform.

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