Firstly, the seismic damage of the brick-concrete structure is analyzed, and the external cause of the failure of the masonry structure under the action of strong earthquake is ground motion, and the internal cause is the structural characteristics. Seismic structural measures for multi-layer brick-concrete structures are proposed, and the structural measures stipulated in the specification are all to ensure the integrity of the house and increase the ductility. In the seismic test of multi-storey masonry houses, it is pointed out that the essence of seismic verification of multi-layer brick-concrete structure is to review the horizontal shear strength of the wall. The seismic measures taken by the building, including the seismic isolation and damping of the building structure, the construction quality and the problems existing in the current construction of multi-storey brick houses, are discussed, which are of great significance to the seismic design of multi-storey masonry houses.